Spring 2021 – Math 150 HW

Methods in Biostatistics

Math 150, Spring 2021

Jo Hardin
2351 Estella Laboratory
jo.hardin@pomona.edu

See Sakai for all relevant links

Office Hours (on Discord, see Sakai for link):

Tuesday 8:30-9:30am PT and 1:30 – 3pm PT

Thursday 7-8am PT and 12-2pm PT

Friday 9-10:30am PT

or by appointment

Text: Practicing Statistics, Kuiper & Sklar (CD information (datasets and R code) on Sakai.)

homework assignments

Important Dates:

  • Exam 1 (date: Wednesday, March 17)
  • Exam 2 (date: Wednesday, April 28)
  • Final Data Analysis Project (date: data viz on Wednesday May 5; Final report on Thursday May 13)

Handouts:

 
Date Topic Section HW Due:

Friday (midnight PT) to Gradescope

Handouts / article link for class discussion Warm-ups (due by 5pm PT next day, Gradescope)
Mon 1/25 Intro       Warm-up 1: 1/25
Wed 1/27 t-tests 2.2 syllabus quiz (not an actual “quiz”): syllquiz.Rmd syllquiz.pdf just read through once (don’t need to know all the details)

Trial Design of AstraZenica

Warm-up 2: 1/27
Mon 2/1 SLR 2.3     Warm-up 3: 2/1
Wed 2/3 Fisher’s Exact Test 6.2 – 6.4 HW1 as Rmd

HW1 as pdf

  Warm-up 4: 2/3
Mon 2/8 RR & OR     What is Efficacy? Warm-up 5: 2/8
Wed 2/10 Chi-sq test 6.5 – 6.6 HW2 as Rmd

HW2 as pdf

  Warm-up 6: 2/10
Mon 2/15 Logistic regression 7.1 – 7.3   read (at least) the paragraph headed “Bivariate Analyses

Case-Control Study of Use of Personal Protective Measures and Risk for SARS-CoV 2 Infection, Thailand

Warm-up 7: 2/15
Wed 2/17   7.4-7.6 HW3 as Rmd

HW3 as pdf

  Warm-up 8: 2/17
Mon 2/22 Logistic regression 7.8   Obesity in Children Plummets

 

JAMA article here

(see Table 6)

we didn’t have time!
Wed 2/24   7.9 – 7.10 HW4 as Rmd

HW4 as pdf

  Warm-up 9: 2/24
Mon 3/1 Model Building     Pfizer, AstraZeneca COVID vaccines are not yet approved for kids. How are clinical trials run for children? Warm-up 10: 3/1
Wed 3/3 ROC    HW5 as Rmd

HW5 as pdf

  Warm-up 11: 3/3
Mon 3/8     Spring Break    
Wed 3/10     Spring Break    
Mon 3/15 Cross Validation     What about the argument of restaurant owners?

Virus spread without mask mandates

Warm-up 12: 3/15
Wed 3/17 review   not due:

HW6 as Rmd

HW6 as pdf

Exam 1

  No warm-up today
Mon 3/22 Survival Analysis: KM 9.1-9.4   Michalowicz et al., NEJM 2006 Warm-up 13: 3/22
Wed 3/24 KM CI 9.5     Warm-up 14: 3/24
Mon 3/29 Log-Rank test 9.6   Lamure et al. EClinical Medicine 2020 Warm-up 15: 3/29
Wed 3/31 Hazard Functions 9.8 HW7 as Rmd

HW7 as pdf

  Warm-up 16: 3/31
Mon 4/5 Cox PH model     What is behind an FDA stamp?  
Wed 4/7 Multiple Cox PH model   HW8 as Rmd

HW8 as pdf

  Warm-up 17: 4/7
Mon 4/12 Assessing PH     Why Most Published Research Findings are False“, Ioannidis, PLoS Medicine, 2005

Science problems

Abuse of Power

CHD HR tables from Dupont

Warm-up 18: 4/12

Wed 4/14 Most published research is FALSE 1.13 HW9 as Rmd

HW9 as pdf

   Warm-up 19: 4/14
Mon 4/19 Multiple Comparisons   First project assignment due: EDA & idea for “something new” What does “no effect” mean?

Tweet

Editorial

Response to Editorial

Full article (no need to read the entire thing)

no warm-up today
Wed 4/21 q-values   HW10 as Rmd

HW10 as pdf

  Warm-up 20: 4/21
Mon 4/26 Stopping Criteria     Pausing Trials

NYT 10/14/20

Warm-up 21: 4/26
Wed 4/28     Exam 2    
Mon 5/3 Poisson regression 8 Optional rough draft of Project due Public health, vaccines, and laws

Jacobson v. Massachusetts

 
Wed 5/5     Project Data Viz    
Thurs 5/13     Final Project due